Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway.In HR, Rad52 facilitates the Neck Support formation of Rad51 nucleoprotein filaments on RPA-coated ssDNA.Here, we decipher how Rad52 functions using single-particle cryo-electron microscopy and biophysical approaches.We report that Rad52 is a homodecamer